Scans have revealed the defender will have to spend almost half a year on the sidelines after he was hurt on duty for the Tigers.
Moses Odubajo has been ruled out for up to six months after he injured his cruciate ligaments during Hull City’s game against Grimsby Town.
The defender, who only joined the Tigers from Brentford played a key role in the team’s promotion to the English Premier League with four assists from 53 appearances.
It was hoped that the injury would not be as bad as first feared but scan confirmed ligament damage, and the player might not play again this year.
“First and foremost, it’s desperately disappointing news for Moses,” manager Steve Bruce told club website.
“He was exceptional for us last season as we won promotion back to the Premier League and we expect him to be a top player for many years to come.
“I know how much he was looking forward to testing himself in the top-flight of English football and to now have to sit out the first half of the season is a big blow – both for him and for the club.
“Looking at the positives, at least the injury is not at the same level as the one suffered by Robert Snodgrass at the start of the 2014/15 season and, as a result, we will look forward to seeing Moses return to training in the New Year.